Tantoo is a member of the Order of Canada (2009) and has worked steadily in film and television on both sides of the border for over 40 years, appearing in over 100 film and television projects. She is known for Blackstone; Dances with Wolves; Black Robe; Dr. Quinn, Medicine Woman; North of 60; Legends of the Fall and Loyalties. She has won numerous awards for her performances: A Gemini for North of 60, a First Americans in the Arts Awards for The Education of Little Tree, an American Indian Film Festival Best Actress Award for Where the Rivers Flow North, a Women in Film Award (Vancouver International Film Festival) for Mothers & Daughters, a Leo Award for Blackstone, and she shares a Best Ensemble Cast Award (Philadelphia FirstGlance Film Festival) for Shouting Secrets. She was nominated for a Genie for Loyalties.